Busulfan is a chemotherapy drug that is a cell cycle non-specific alkylating agent (slows the growth of cancer cells). More specifically it belongs to a subclass of alkylating agents known as alkyl sulfonates. It is marketed in the U.S. by GlaxoSmithKline under the brand name Myleran, and has been in clinical use since 1959. Busulfan is also available in an IV formulation marketed as Busulfex by PDL BioPharma, Inc. Its chemical designation is 1,4-Butanediol dimethanesulfonate. Product name: Busulfan(Myleran,Busulfex) Molecular formula: C6H14O6S5
CAS No.: 55-98-1
Molecular Weight: 246.3
Structural Formula:  Busulfan
Properties: White crystalline powder.melting point: 114 ~ 118'C, insoluble in water, solubility in 25'C acetone: 2.4g/100ml,ethanol solubility: 0.1g/100ml,almost odorless.
Quality standard: In accordance with CP2000.
Use: Antineoplastic medicine.
1. Busulfan is used to treat chronic myelogenous leukemia (CML).
2. Also used to treat certain blood disorders such as polycythemia vera and myeloid metaplasia.
3. Used in some conditioning regimens prior to bone marrow transplant.
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