Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy. These two anticancer agents, in vivo, may be converted to urotoxic metabolites such as acrolein. Mesna assists to neutralise these metabolites by binding through its sulfhydryl-moieties, and also increases urinary excretion of cysteine.

Chemical name: Sodium 2-mercaptoethanesulphonate

Product name: Mesna(Mitoxana®);Sodium 2-mercaptoethanesulphonate;

Structural Formula:HSCH2CH2SO3Na

Molecular Formula:C2H5NaO3S2

Molecular Weight: 164.18

CAS NO. : [19767-45-4]

Properties: Mesna is a clear fluid. It is also available as tablets, white crystal.

Quality Standard:CP2000

Use: Can be used as urethra protectant.Mesna is used to protect the bladder and kidneys from the effects of the chemotherapy drugs ifosfamide (Mitoxana®) and cyclophosphamide. Mesna is not a chemotherapy drug. This information describes mesna, how it is given, and some of its possible side effects.


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